![]() ![]() The objective is (1) To evaluate the change in forced expiratory volume in one second (FEV1), forced vital capacity (FVC), dyspnea grading, body mass index, and oxygen saturation (SpO2) in adults with postinfectious obliterative bronchiolitis (PIOB) over a period of time (2) To evaluate the same parameters in chronic obstructive pulmonary disease (COPD) patients and compare with PIOB. 15 Based on the reported histologic findings in EVALI, with most cases demonstrating primarily airway-centered acute lung injury, it has been postulated that this represents a form of airwaycentered chemical pneumonitis from one or more inhaled Chronic aspiration excluded due to the following: -Constrictive bronchiolitis seen in patients 1-4 not known to occur in association with chronic aspiration -Patient 2: GERD well-controlled on omeprazole at presentation lack of histiocytic inflammation frequently present in chronic aspiration -Patients 1, 3, and 4: no known history of GERD * ANA denotes antinuclear antibody, CTD connective tissue disease, GERD gastroesophageal reflux disease, ILD interstitial lung disease, PFT pulmonary function test, and PPD packs per day. Constrictive bronchiolitis and other small airway fibrotic syndromes can present with asthma-like symptoms due to fibrotic narrowing of the small airways. Constrictive bronchiolitis (also known as obliterative bronchiolitis or bronchiolitis obliterans) is a well-established pathologic sequelae of chronic small airway injury from inhalational chemical fume exposures.
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